Why the study?
Does coadministration of roflumilast and digoxin alter the pharmacokinetics of either drug in healthy adults?
Does coadministration of roflumilast and digoxin alter the pharmacokinetics of either drug in healthy adults?
Coadministration of roflumilast and digoxin does not result in clinically significant pharmacokinetic interactions, indicating roflumilast is not a P-glycoprotein inhibitor.
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Supports safe coadministration without dose adjustment; confirms roflumilast is not a P-glycoprotein inhibitor.
Eckermann et al. (2011) studied this question.
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