Why the study?
Does coadministration of talinolol alter the pharmacokinetics of oral digoxin in healthy volunteers?
Does coadministration of talinolol alter the pharmacokinetics of oral digoxin in healthy volunteers?
Oral coadministration of talinolol significantly increases the bioavailability of oral digoxin, likely due to competition for intestinal P-glycoprotein.
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May increase digoxin exposure with talinolol; leaves open clinical relevance and monitoring needs in patients.
Kristin Westphal (2000) studied this question.
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