Why the study?
Do calcium antagonists and antiarrhythmic drugs alter plasma digoxin concentration and its cardioactive effects in healthy men on steady-state digoxin?
Population
36 healthy men during digoxin steady state (0.375 mg/day)
Comparison
Calcium antagonists and antiarrhythmic drugs… vs Placebo administered three times a day for 2 weeks
Design
RCT, Randomly assigned to three subgroups and each group received placebo and…
Follow-up
2 weeks per regimen
Authors
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Monitor digoxin levels with these co-treatments; confirms renal clearance reduction as primary interaction mechanism.
Do calcium antagonists and antiarrhythmic drugs alter plasma digoxin concentration and its cardioactive effects in healthy men on steady-state digoxin?
Various calcium antagonists and antiarrhythmic drugs significantly increase plasma digoxin concentrations and its cardioactive effects, primarily by decreasing renal digoxin clearance.
Belz et al. (1983) studied this question.
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