Key result
Quinidine administration in digitalized patients increased serum digoxin concentration by ≥0.5 nmol/L in 95.5% of patients, compared to 2.4% of those receiving alternative antiarrhythmics.
Why the study?
Does quinidine compared to other antiarrhythmic drugs increase serum digoxin concentration in digitalized patients?
Population
63 digitalized patients
Comparison
Quinidine vs Procainamide, disopyramide, or mexiletine
Design
Cohort
Authors
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Quinidine was associated with marked digoxin level rises in digitalized patients; leaves open whether this interaction warrants avoiding quinidine pending randomized confirmation.
Cohort (n=63)
Does quinidine compared to other antiarrhythmic drugs increase serum digoxin concentration in digitalized patients?
Absolute Event Rate: 95.5% vs 2.4%
Quinidine, unlike procainamide, disopyramide, or mexiletine, significantly increases serum digoxin concentrations, prolongs the PR interval, and causes more gastrointestinal side effects in digitalized patients.
Edward B. Leahey (1980) conducted a cohort in Patients receiving digoxin (n=63). Quinidine vs. Procainamide, disopyramide, or mexiletine was evaluated on Increase in serum digoxin concentration by ≥0.5 nmol/L. Quinidine administration in digitalized patients increased serum digoxin concentration by ≥0.5 nmol/L in 95.5% of patients, compared to 2.4% of those receiving alternative antiarrhythmics.
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