Key result
Verapamil coadministration increased plasma digoxin by 60-80% and was associated with a more sustained reduction in left ventricular ejection time compared to control.
Why the study?
Does verapamil coadministration alter digoxin-induced inotropism and plasma digoxin concentrations?
Population
Subjects in single-dose trials and human lymphocytes for in-vitro studies
Comparison
Verapamil coadministration with digoxin vs Control (digoxin alone)
Design
Other
Authors
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May warrant digoxin monitoring with verapamil; leaves open randomized confirmation of net clinical effects.
Does verapamil coadministration alter digoxin-induced inotropism and plasma digoxin concentrations?
Verapamil coadministration significantly increases plasma digoxin levels and its inotropic and potentially toxic effects, necessitating careful monitoring when these drugs are combined.
Knud Erik Pedersen (1984) reported a review. Verapamil vs. Control was evaluated on Left ventricular ejection time. Verapamil coadministration increased plasma digoxin by 60-80% and was associated with a more sustained reduction in left ventricular ejection time compared to control.
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