Key result
Verapamil significantly reduced nonrenal clearance of digoxin from 7.01 to 4.00 L/hr (P<0.05), whereas isradipine showed no clinically relevant interaction.
Why the study?
Does verapamil or isradipine alter the pharmacokinetics of intravenous digoxin in healthy male subjects?
Population
24 healthy, male, nonobese volunteer subjects, aged 18 to 38 years.
Comparison
Verapamil orally over 15 days, followed by 1 mg… vs Isradipine orally over 15 days, followed by 1 mg…
Design
Other
Follow-up
72 hours after intravenous digoxin
Authors
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Requires caution with verapamil-digoxin coadministration; leaves open isradipine preference in clinical populations.
Does verapamil or isradipine alter the pharmacokinetics of intravenous digoxin in healthy male subjects?
p-value: p=<0.05
Verapamil, but not isradipine, significantly reduces the nonrenal and total clearance of digoxin, leading to its accumulation and potential toxicity.
Johnson et al. (1987) studied Healthy volunteers (n=24). Verapamil vs. Isradipine was evaluated on Nonrenal and total clearance of digoxin (p=<0.05). Verapamil significantly reduced nonrenal clearance of digoxin from 7.01 to 4.00 L/hr (P<0.05), whereas isradipine showed no clinically relevant interaction.
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