Why the study?
Does intravenous isradipine compared to verapamil affect cardiac electrophysiology in patients with normal electrophysiological profiles?
Population
19 patients with normal cardiac electrophysiological profiles
Comparison
Isradipine intravenously at doses of 0.0010… vs Verapamil intravenously at 0.0125, 0.0250…
Design
RCT, randomized
Follow-up
acute (during IV administration)
Authors
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Supports isradipine for BP control without conduction slowing; extends evidence of differential calcium channel blocker effects on AV node.
Does intravenous isradipine compared to verapamil affect cardiac electrophysiology in patients with normal electrophysiological profiles?
Intravenous isradipine demonstrates electrophysiological neutrality on the cardiac conduction system, unlike verapamil, despite causing significant blood pressure reduction.
Tullo et al. (1993) studied this question.
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