Why the study?
Does dexamethasone reverse the antiarrhythmic effects of pacing-induced preconditioning in dogs with induced myocardial ischemia?
Population
Dogs subjected to left anterior descending coronary artery occlusion for 25 min
Comparison
Dexamethasone followed by rapid cardiac pacing vs Rapid cardiac pacing alone, and unpaced dogs
Design
Preclinical
Follow-up
24 hours
Authors
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Reverses antiarrhythmic protection of pacing in canine ischemia; leaves open whether glucocorticoids blunt preconditioning in patients.
Does dexamethasone reverse the antiarrhythmic effects of pacing-induced preconditioning in dogs with induced myocardial ischemia?
Dexamethasone reverses the antiarrhythmic protection of pacing-induced preconditioning in a canine model of ischemia.
Végh et al. (1994) studied this question.
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