Population
Preclinical models of cardiac hypertrophy stimulated with isoproterenol and aldosterone
Design
Preclinical
Authors
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Hypothesis-generating for miR-9 in hypertrophy models; leaves open translation to human HF prevention.
The study identifies a novel molecular pathway where miR-9 attenuates cardiac hypertrophy by suppressing myocardin, offering a potential therapeutic target for preventing heart failure.
Wang et al. (2010) studied this question.