Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 24, 2006Circulation ResearchOpen Access

Myocardin Induces Cardiomyocyte Hypertrophy

View Full Paper
Ask AI
Bookmark
Share

Population

Postnatal cardiomyocytes

Comparison

Forced expression of myocardin or a… vs Control cardiomyocytes or those treated with…

Design

Preclinical

Authors

WXWeibing XingWuhan University of Science and TechnologyTZTong-Cun ZhangWuhan University of Science and TechnologyDCDongsun CaoUniversity of North Carolina at Chapel Hill

Discussion

Loading...

Member takes

Implication

Myocardin targeting should not yet inform clinical decisions; leaves open its role as effector in human cardiac hypertrophy.

Structured PICO

P
Population
Postnatal cardiomyocytes
I
Intervention
Forced expression of myocardin or a dominant-negative mutant form of myocardin
C
Comparator
Control cardiomyocytes or those treated with hypertrophic agonists (phenylephrine and leukemia inhibitory factor)
O
Outcome
Cardiomyocyte hypertrophy and activation of the fetal cardiac gene programsurrogate

Myocardin acts as a critical nuclear effector in hypertrophic signaling pathways, coupling stress signals to postnatal cardiac growth and remodeling.

Cite This Study

Xing et al. (2006) studied this question.

synapsesocial.com/papers/6a6f5a778031ec7bb1dbb520https://doi.org/10.1161/01.res.0000218781.23144.3e
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Target Gene-Specific Modulation of Myocardin Activity by GATA Transcription Factors2004 · 53 citations
  2. 2Genetic Dissection of Cardiac Growth Control Pathways2000 · 290 citations
  3. 3Sizing up the heart: development redux in disease2003 · 392 citations
  4. 4Cardiac Hypertrophy: The Good, the Bad, and the Ugly2003 · 1,467 citations
  5. 5The Atrial Natriuretic Factor Promoter Is a Downstream Target for Nkx-2.5 in the Myocardium1996 · 154 citations