What question did this study set out to answer?

To determine how smooth muscle-specific gene expression is established through ubiquitously expressed serum response factor (SRF) and assess the regulatory role of myocardin.

May 19, 2003Proceedings of the National Academy of SciencesOpen Access

Myocardin is a master regulator of smooth muscle gene expression

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Authors

ZWZhigao WangZhejiang Wanli University DWDa‐Zhi WangUniversity of Miami GPG. C. Teg PipesGlaxoSmithKline (United States)

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Implication

Molecular analysis reveals myocardin activates smooth muscle transcription through serum response factor pairing, indicating its role as a master regulator.

Key Points

To determine how smooth muscle-specific gene expression is established through ubiquitously expressed serum response factor (SRF) and assess the regulatory role of myocardin.
Evaluated the ability of myocardin, a cardiac- and smooth muscle-specific coactivator, to activate smooth muscle gene programs in multiple nonmuscle cell types.
Investigated the functional requirement of myocardin homodimerization and cooperative interaction with SRF complexes bound to distinct promoter sites.
Myocardin activated smooth muscle gene expression in nonmuscle cells through physical and functional association with SRF.
Homodimerization of myocardin was required for maximal transcriptional activity and mediated cooperative activation across multiple SRF binding sites.

Cite This Study

Wang et al. (2003) studied this question.

synapsesocial.com/papers/6a088883ab15ea61dee8e9eb https://doi.org/10.1073/pnas.1232341100

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Implication

Molecular analysis reveals myocardin activates smooth muscle transcription through serum response factor pairing, indicating its role as a master regulator.

Myocardin is a master regulator of smooth muscle gene expression

Discussion

Member takes

Implication

Key Points

Cite This Study

Myocardin is a master regulator of smooth muscle gene expression

Discussion

Member takes

Implication

Key Points

Cite This Study

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