Why the study?
Does dehydroepiandrosterone sulphate reduce pulmonary arterial blood pressure in rats with chronic hypoxic pulmonary hypertension?
Population
Rats exposed to 4 weeks of hypoxia to induce chronic hypoxic pulmonary hypertension
Comparison
Dehydroepiandrosterone sulphate (DHEA-S, 0.1 mg… vs Hypoxic rats not treated with DHEA-S
Design
Preclinical
Follow-up
4 weeks
Authors
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DHEA-S attenuates hypoxic PH in rats; hypothesis-generating for human PAH, no practice change yet.
Does dehydroepiandrosterone sulphate reduce pulmonary arterial blood pressure in rats with chronic hypoxic pulmonary hypertension?
DHEA-S, an activator of calcium-gated potassium channels, reduces hypoxic pulmonary hypertension and associated right ventricular hypertrophy in a rat model.
Hampl et al. (2003) studied this question.
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