June 1, 1998The Journal of General PhysiologyOpen Access

Kinetic Structure of Large-Conductance Ca2+-activated K+ Channels Suggests that the Gating Includes Transitions through Intermediate or Secondary States

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Population

Cultured rat skeletal muscle (single large-conductance Ca2+-activated K+ channels)

Comparison

Two-dimensional analysis of single-channel… vs Standard Monod-Wyman-Changeux (MWC) model

Design

Preclinical

Authors

BRBrad S. RothbergTemple University KMKarl L. MaglebyUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Refines BK channel kinetic models in animals; leaves open relevance to human cardiovascular Ca2+ signaling.

Structured PICO

Population

Cultured rat skeletal muscle (single large-conductance Ca2+-activated K+ channels)

Intervention

Two-dimensional analysis of single-channel currents using patch clamp technique and kinetic modeling

Comparator

Standard Monod-Wyman-Changeux (MWC) model

Outcome

Kinetic structure and gating mechanisms of Ca2+-dependent channelssurrogate

The gating of large-conductance Ca2+-activated K+ channels involves transitions through intermediate or secondary closed states, which account for brief channel flickers.

Cite This Study

Rothberg et al. (1998) studied this question.

synapsesocial.com/papers/6a754d1c756843cacbb1f3ca https://doi.org/10.1085/jgp.111.6.751

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Kinetic Structure of Large-Conductance Ca2+-activated K+ Channels Suggests that the Gating Includes Transitions through Intermediate or Secondary States

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Kinetic Structure of Large-Conductance Ca2+-activated K+ Channels Suggests that the Gating Includes Transitions through Intermediate or Secondary States

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider