Allosteric Gating of a Large Conductance Ca-activated K+ Channel

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Population

Cloned large-conductance Ca-activated potassium channel (BK channel) mslo

Design

Preclinical

Authors

Discussion

Offers no immediate clinical application; extends allosteric gating models for BK channel research.

Population

Cloned large-conductance Ca-activated potassium channel (BK channel) mslo

Intervention

Voltage-dependent Monod-Wyman-Changeux (MWC) kinetic modeling

Outcome

Ability to mimic mslo macroscopic steady state and kinetic behavior

A voltage-dependent Monod-Wyman-Changeux model successfully describes the allosteric gating of BK channels by voltage and intracellular calcium.

Aspects of the mslo data not well fitted by the simplified scheme will likely be better accounted for by a more general scheme based on a homotetramer with a single Ca2+ binding site and a single voltage sensor in each subunit.

Cox et al. (1997) studied this question.

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