Why the study?
Do established late-onset Alzheimer disease risk loci affect the age at onset in affected participants?
Population
9,162 participants of white race/ethnicity with late-onset Alzheimer disease occurring after age 60 years…
Comparison
Presence of risk alleles at 10 confirmed… vs Absence of these risk alleles / baseline genetic…
Design
Meta-analysis
Authors
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APOE may refine onset-age predictions in late-onset Alzheimer disease; confirms modest collective contribution from other established loci.
Do established late-onset Alzheimer disease risk loci affect the age at onset in affected participants?
While APOE variants strongly influence the age at onset of late-onset Alzheimer disease, the combined effects of other known risk variants are significant but individually small.
Naj et al. (2014) studied this question.
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