Key result
APOE4 allele linked to ~255% higher risk of late-onset Alzheimer disease.
Why the study?
Few data exist related to gene/gene and gene/environment risk interactions in late onset Alzheimer Disease (LOAD).
What are the gene/gene and gene/environment associations in late onset Alzheimer Disease?
Population
153 subjects with LOAD and 302 gender matched controls
Comparison
Gene/gene and gene/environment interactions including APOE, ACE, OLR1, CYP46 and environmental factors
Design
Pilot case-control study using population-based bio-repository
Authors
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May inform familial AD risk assessment; leaves open gene-environment interactions with smoking for prospective confirmation.
Case-Control (n=455)
What are the gene/gene and gene/environment associations in late onset Alzheimer Disease?
Odds Ratio: 3.55 (95% CI 1.7–7.45)
This pilot study identified significant associations between APOE4, smoking, and late-onset Alzheimer Disease, suggesting potential gene-environment interactions.
Ghebranious et al. (2010) conducted a case-control in Late onset Alzheimer Disease (LOAD) (n=455). APOE4 allele vs. Absence of APOE4 allele was evaluated on Late onset Alzheimer Disease (LOAD) (OR 3.55, 95% CI 1.70-7.45). The APOE4 allele was significantly associated with an increased risk of late onset Alzheimer Disease (OR 3.55; 95% CI 1.70-7.45).
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