Rhodium‐Catalyzed Asymmetric Intramolecular Hydroamination of Allenes

This is the authors' abstract. We don't add key points for this paper.

The rhodium-catalyzed asymmetric intramolecular hydroamination of sulfonyl amides with terminal allenes is reported. It provides selective access to 5- and 6-membered N-heterocycles, scaffolds found in a large range of different bioactive compounds. Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof are demonstrated.