Why the study?
Does the combination of antihypertensive medications and cholinesterase inhibitors reduce cognitive decline in patients with Alzheimer's disease and hypertension?
Population
617 patients with probable Alzheimer's disease and concomitant hypertension from the University of…
Comparison
Antihypertensive medications and cholinesterase… vs Patients not taking antihypertensive…
Design
Cohort
Follow-up
up to 5 years
Authors
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Should not change prescribing in hypertensive AD; leaves open synergistic aHTN-ChEI effects for prospective validation.
Does the combination of antihypertensive medications and cholinesterase inhibitors reduce cognitive decline in patients with Alzheimer's disease and hypertension?
The combination of antihypertensive medications (specifically diuretics, CCBs, and RAAS inhibitors) and cholinesterase inhibitors synergistically slows cognitive decline in patients with Alzheimer's disease and hypertension.
Hu et al. (2018) studied this question.
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