Population
Cultured cells and Hepatitis Delta Virus (HDV) RNA substrates
Design
Preclinical
Authors
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Minimal ADAR substrates for HDV editing identified; leaves open antiviral applications pending human validation.
The study identifies the minimal HDV RNA substrates required for editing by hADAR1 (24 nucleotides) and hADAR2 (66 nucleotides), with the hADAR1 substrate being the smallest ADAR substrate identified to date.
Sato et al. (2001) studied this question.
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