October 11, 2019VirusesOpen Access

Structural Pattern Differences in Unbranched Rod-Like RNA of Hepatitis Delta Virus Affect RNA Editing

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Structured PICO

Population

Hepatitis delta virus (HDV) RNA (20 mutants and 41 naturally occurring HDV genomes)

Intervention

Mutants carrying an increased length of consecutive base-pairing (16 or 17 consecutive base pairs)

Comparator

Naturally occurring HDV genomes and mutants with up to 15 consecutive base pairs

Outcome

amber/W site RNA editing efficiencysurrogate

Extended base-pairing upstream of the amber/W site increases HDV RNA editing efficiency, suggesting natural HDV RNA structures are selected for suboptimal editing to favor replication.

Discussion

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Implication

Refines HDV editing models via length mutants; leaves open therapeutic translation for clinicians.

Cite This Study

Hsu et al. (2019) studied this question.

synapsesocial.com/papers/6a866492fb63d0a2a03a7352 https://doi.org/10.3390/v11100934

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Structural Pattern Differences in Unbranched Rod-Like RNA of Hepatitis Delta Virus Affect RNA Editing

Structured PICO

Discussion

Implication

Cite This Study

Structural Pattern Differences in Unbranched Rod-Like RNA of Hepatitis Delta Virus Affect RNA Editing

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider