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January 1, 2015Journal of Korean Medical ScienceOpen Access

Significantly lower CIMT was observed in RA patients with MTX compared to those without MTX (0.644 ± 0.136 mm vs 0.767 ± 0.233 mm, P < 0.05), with effects correlating with MTX dosage (β = -0.029, P < 0.01).

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Why the study?

Does methotrexate reduce carotid intima-media thickness in female patients with rheumatoid arthritis?

Population

66 females, comprising 44 patients with rheumatoid arthritis and 22 age-matched healthy controls.

Comparison

Methotrexate (MTX) vs Rheumatoid arthritis patients not taking…

Design

Case-control

Authors

HKHyun-Je KimMKMin Jung KimCLChoong Ki Lee

Discussion

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Overview

MTX use was associated with lower CIMT in RA; leaves open CV protective effect pending randomized trials.

Structured PICO

Does methotrexate reduce carotid intima-media thickness in female patients with rheumatoid arthritis?

P
Population
66 females, comprising 44 patients with rheumatoid arthritis (meeting 2010 ACR/EULAR criteria) and 22 age-matched healthy controls.
I
Intervention
Methotrexate (MTX)
C
Comparator
Rheumatoid arthritis patients not taking methotrexate, and healthy controls
O
Outcome
Carotid intima-media thickness (CIMT) measured by B-mode ultrasoundsurrogate

Methotrexate use in rheumatoid arthritis patients is associated with reduced carotid intima-media thickness, suggesting a potential protective effect against cardiovascular disease.

Cite This Study

Kim et al. (2015) studied this question.

synapsesocial.com/papers/6a75599701b447f0dadc16edhttps://doi.org/10.3346/jkms.2015.30.11.1589
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A study of carotid intima media thickness in patients with rheumatoid arthritis and its correlation with acute phase reactants and disease activity2024
  2. 2Rheumatoid arthritis is an independent risk factor for increased carotid intima-media thickness: impact of anti-inflammatory treatment2010 · 57 citations
  3. 3A Study of Assessment of Preclinical Atherosclerosis by Carotid Intima-media Thickness in Newly Diagnosed Patients with Rheumatoid Arthritis Younger than 50 Years of Age and Their Correlation with Disease Activity: A Comparative, Cross-sectional Study2024 · 1 citations
  4. 4Association of Cardiovascular Risk Factors with Carotid Intima Media Thickness in Patients with Rheumatoid Arthritis with Low Disease Activity Compared to Controls: A Cross-Sectional Study2015 · 27 citations
  5. 5Methotrexate, blood pressure and markers of arterial function in patients with rheumatoid arthritis: a repeated cross-sectional study2017 · 49 citations