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July 1, 2026Journal of Clinical MedicineOpen Access

Carotid Atherosclerosis and T-Cell Imbalance in Women with Rheumatoid Arthritis: A Cross-Sectional Study of Intima–Media Thickness, Anti-CCP Antibodies and CD4/CD8 Ratio

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Authors

EDElena DeseatnicovaANAlesea NistorATAna Tigulea

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Overview

Cross-sectional study compares carotid IMT in women with rheumatoid arthritis to controls, suggesting cardiovascular monitoring.

Key Points

  • This study aims to compare carotid intima-media thickness (IMT) in women with rheumatoid arthritis (RA) and controls, and examine relationships with inflammatory markers.
  • Cross-sectional study involving 59 women with RA and 55 age-matched controls.
  • Carotid IMT measured using B-mode ultrasonography and correlated with various clinical parameters.
  • Participants received methotrexate and had no recent biologic DMARD exposure.
  • Mean carotid IMT was significantly higher in RA patients (0.85 ± 0.09 mm) than in controls (0.63 ± 0.08 mm, p < 0.0001).
  • Significant positive correlations of IMT with disease duration (r = 0.48, p < 0.001), years since menopause (ρ = 0.44, p = 0.001), anti-CCP titers (r = 0.31, p = 0.018) and CD4/CD8 ratio (r = 0.42, p < 0.001).
  • In multivariable analysis, RA duration and CD4/CD8 ratio were independently associated with IMT.

Cite This Study

Deseatnicova et al. (2026) studied this question.

synapsesocial.com/papers/6a44af895cd2549c8bc44752https://doi.org/10.3390/jcm15135054
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rheumatoid arthritis is an independent risk factor for increased carotid intima-media thickness: impact of anti-inflammatory treatment2010 · 57 citations
  2. 2Association of Cardiovascular Risk Factors with Carotid Intima Media Thickness in Patients with Rheumatoid Arthritis with Low Disease Activity Compared to Controls: A Cross-Sectional Study2015 · 27 citations
  3. 3Carotid intima-media thickness in middle-aged adults with and without rheumatoid arthritis: a case-cohort analysis2025
  4. 4Do Carotid Artery Diameters Manifest Early Evidence of Atherosclerosis in Women with Rheumatoid Arthritis?2008 · 32 citations
  5. 5A study of carotid intima media thickness in patients with rheumatoid arthritis and its correlation with acute phase reactants and disease activity2024