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December 23, 2008Journal of Women s HealthOpen Access

Do Carotid Artery Diameters Manifest Early Evidence of Atherosclerosis in Women with Rheumatoid Arthritis?

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Why the study?

Does rheumatoid arthritis increase carotid artery diameters and atherosclerosis markers in women compared to healthy controls?

Population

186 women, comprising 93 women with rheumatoid arthritis and 93 healthy women matched by age, race, and…

Comparison

Rheumatoid arthritis diagnosis vs Healthy women matched by age, race, and…

Design

Cross-sectional, Ultrasound scans read by technicians blinded to study group

Authors

LSLaura L. SchottAKAmy KaoACAmy Cunningham

Discussion

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Overview

Larger carotid diameters may indicate early vascular changes in RA women; leaves open prognostic utility and need for longitudinal validation.

Structured PICO

Does rheumatoid arthritis increase carotid artery diameters and atherosclerosis markers in women compared to healthy controls?

P
Population
186 women, comprising 93 women with rheumatoid arthritis (RA) (mean age 53.3 years, median RA duration 14 years) and 93 healthy women matched by age, race, and menopause status.
I
Intervention
Rheumatoid arthritis diagnosis (observational exposure)
C
Comparator
Healthy women matched by age, race, and menopause status
O
Outcome
Carotid artery measures including lumen diameter, interadventitial diameter, intima-media thickness (IMT), and presence of plaquesurrogate

Women with rheumatoid arthritis have increased carotid artery diameters compared with healthy women, which may reflect premature vascular aging and serve as an early indicator of increased cardiovascular risk.

Limitations

  • Missing diameter measures for 18 subjects
  • Cross-sectional design without correction for multiple comparisons
  • Convenience sample of controls recruited as part of another study and matched retrospectively

Cite This Study

Schott et al. (2008) studied this question.

synapsesocial.com/papers/6a201f6d76ec520ee9a1b189https://doi.org/10.1089/jwh.2008.0797
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carotid Atherosclerosis and T-Cell Imbalance in Women with Rheumatoid Arthritis: A Cross-Sectional Study of Intima–Media Thickness, Anti-CCP Antibodies and CD4/CD8 Ratio2026 · 1 citations
  2. 2Rheumatoid arthritis is an independent risk factor for increased carotid intima-media thickness: impact of anti-inflammatory treatment2010 · 57 citations
  3. 3A Study of Assessment of Preclinical Atherosclerosis by Carotid Intima-media Thickness in Newly Diagnosed Patients with Rheumatoid Arthritis Younger than 50 Years of Age and Their Correlation with Disease Activity: A Comparative, Cross-sectional Study2024 · 1 citations
  4. 4Association of Cardiovascular Risk Factors with Carotid Intima Media Thickness in Patients with Rheumatoid Arthritis with Low Disease Activity Compared to Controls: A Cross-Sectional Study2015 · 27 citations
  5. 5Carotid Intima–Media Thickness and Narrowing in Rheumatoid Arthritis: Impact of Age, Diabetes, and Conventional Risk Factors2026