February 22, 2006The Journal of Clinical Endocrinology & MetabolismOpen Access

Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome

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Population

200 women with PCOS (defined as irregular menses and hyperandrogenism) from an academic endocrinology clinic.

Design

Cohort

Authors

TSTracy L. SetjiEndocrinology Research Center NHNicole D. HollandAmerican Society of Clinical Oncology LSLinda SandersUniversity of Colorado Anschutz Medical Campus

Discussion

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Implication

May mark metabolic risk in PCOS; hypothesis-generating and should not yet change practice.

Structured PICO

Population

200 women with PCOS (defined as irregular menses and hyperandrogenism) from an academic endocrinology clinic.

Outcome

Biopsy-documented NASH and aminotransferase levelssurrogate

Abnormal aminotransferase activity is common in young women with PCOS and is associated with metabolic derangements including low HDL, high triglycerides, and high fasting insulin, with some patients already exhibiting biopsy-proven NASH with fibrosis.

Cite This Study

Setji et al. (2006) studied this question.

synapsesocial.com/papers/6a755c62508d802509f55d90 https://doi.org/10.1210/jc.2005-2774

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Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider