Why the study?
Does streptokinase treatment following myocardial infarction cause histopathological changes in the heart?
Does streptokinase treatment following myocardial infarction cause histopathological changes in the heart?
Streptokinase treatment for myocardial infarction is associated with massive interstitial hemorrhage into necrotic tissue, likely due to reperfusion.
May signal reperfusion hemorrhage risk with streptokinase post-MI; leaves open clinical impact and need for prospective studies.
Examination of 27 hearts from patients treated by streptokinase following myocardial infarction showed one major histopathological difference from controls, the presence of massive interstitial haemorrhage into the necrotic tissue in some cases. This change is presumably related to the re-establishment of the circulation to infarcted areas.
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C. L. Berry (1975) studied this question.
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