Why the study?
Does adaptation to beta-blockers alter heart rate, blood pressure, and QT interval in hypertensive and normotensive subjects?
Population
19 subjects (14 hypertensive patients and 5 normotensive subjects)
Comparison
Oral propranolol 80 mg or metoprolol 100 mg… vs Baseline and 54 hours after cessation of…
Design
Cohort
Follow-up
31 days of active treatment followed by 2 weeks of placebo
Authors
Loading...
Supports distinct BP/HR adaptation mechanisms with QT prolongation; hypothesis-generating for long-term effects and outcomes.
Does adaptation to beta-blockers alter heart rate, blood pressure, and QT interval in hypertensive and normotensive subjects?
Adaptation to beta-blockade results in uncorrelated reductions in blood pressure and heart rate, alongside prolonged QT intervals, without hypersensitivity to intravenous beta-blockers.
Birkhead et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: