What question did this study set out to answer?

To evaluate the feasibility, safety, effectiveness, and predictors of success for transcatheter edge-to-edge tricuspid valve repair using the MitraClip system in high surgical risk patients.

June 1, 2018EuroIntervention

Transcatheter treatment of tricuspid regurgitation using edge-to-edge repair: procedural results, clinical implications and predictors of success

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Why the study?

Does transcatheter edge-to-edge repair using the MitraClip system reduce tricuspid regurgitation severity in high-risk patients?

Key Points

To evaluate the feasibility, safety, effectiveness, and predictors of success for transcatheter edge-to-edge tricuspid valve repair using the MitraClip system in high surgical risk patients.
Assessed 42 elderly high-risk patients (mean age 76.8±7.3 years, EuroSCORE II 8.1±5.7) with severe tricuspid regurgitation (TR) undergoing isolated tricuspid repair (n=11) or combined tricuspid and mitral edge-to-edge repair (n=31).
Analyzed procedural success, clip locations, reductions in regurgitation severity, functional improvements, and success predictors at 30-day follow-up.
Procedural success was achieved in 83% of patients (35/42), resulting in a 62.5% reduction in effective regurgitant orifice area from 0.8±0.4 to 0.3±0.2 cm² (p<0.0001).
Six-minute walking distance increased significantly in both isolated tricuspid repair (285±118 to 344±81 m, p=0.02) and combined repair cases (225±113 to 261±130 m, p=0.03).
Predominant anteroseptal or central tricuspid regurgitation significantly predicted procedural success (p=0.025).

Structured PICO

Does transcatheter edge-to-edge repair using the MitraClip system reduce tricuspid regurgitation severity in high-risk patients?

Population

42 elderly high-risk patients (mean age 76.8±7.3 years, EuroSCORE II 8.1±5.7) with isolated tricuspid regurgitation (TR) (n=11) or combined TR and mitral regurgitation (MR) (n=31).

Intervention

Transcatheter edge-to-edge repair of the tricuspid valve using the MitraClip system (either isolated or combined with mitral valve repair).

Outcome

Procedural success, impact on TR severity (effective regurgitant orifice area), and predictors of success at 30-day follow-up.surrogate

Transcatheter edge-to-edge repair of the tricuspid valve using the MitraClip system is feasible and effectively reduces tricuspid regurgitation severity while improving functional capacity in high-risk patients.

Discussion

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Implication

TV edge-to-edge repair with MitraClip appears feasible in high-risk patients; leaves open efficacy and safety confirmation in randomized trials.

Cite This Study

Lurz et al. (2018) studied this question.

synapsesocial.com/papers/6a75639496d04a2f43f593d9 https://doi.org/10.4244/eij-d-17-01091

Topics

Tricuspid regurgitation

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Implication

TV edge-to-edge repair with MitraClip appears feasible in high-risk patients; leaves open efficacy and safety confirmation in randomized trials.

Transcatheter treatment of tricuspid regurgitation using edge-to-edge repair: procedural results, clinical implications and predictors of success

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Transcatheter treatment of tricuspid regurgitation using edge-to-edge repair: procedural results, clinical implications and predictors of success

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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