Why the study?
Do ACE and AT1R gene polymorphisms associate with hypertension in the Indian population?
Population
105 hypertensive subjects and 192 controls from the Indian population
Comparison
I/D polymorphism of angiotensin I converting… vs Controls without hypertension
Design
Case-control
Authors
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May support D allele as early-onset hypertension marker in Indians; leaves open ACE/AT1R genotype associations with overall risk.
Do ACE and AT1R gene polymorphisms associate with hypertension in the Indian population?
While ACE and AT1R genotypes are not directly associated with overall hypertension risk in the Indian population, the ACE D allele may serve as a predictor for early onset of the disease.
Ashavaid et al. (2000) studied this question.
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