Interaction between Wall Shear Stress and Circumferential Strain Affects Endothelial Cell Biochemical Production

Bovine aortic endothelial cells (ECs) cultured on the inner surface of compliant tubes

Exposure to various flow conditions including steady shear (10 dyn/cm2), oscillatory shear (10 +/- 10 dyn/cm2, rigid tube), and oscillatory shear (10 +/- 10 dyn/cm2) with circumferential strain (8%) either in or out of phase with shear

Comparison between different flow conditions (steady shear vs oscillatory shear vs oscillatory shear with circumferential strain)

4-hour production rates of vasodilators (prostacyclin and nitric oxide) and a vasoconstrictor (endothelin-1)surrogate