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January 1, 2008Hypertension in Pregnancy

Prediction of Maternal Predisposition to Preeclampsia

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Why the study?

Can a stepwise prediction index based on patient history, laboratory, and clinical parameters accurately identify women at high risk for developing preeclampsia?

Population

151 nonpregnant women, including 101 with a history of preeclampsia and 50 parous women with a history of…

Design

Case-control

Authors

PEPatrick EmontsUniversité Libre de BruxellesSSSontera SeaksanUniversity of LiègeLSLaurence SeidelUniversity of Liège

Discussion

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Implication

May aid preeclampsia risk stratification in pregnancy; leaves open need for prospective validation before clinical use.

Structured PICO

Can a stepwise prediction index based on patient history, laboratory, and clinical parameters accurately identify women at high risk for developing preeclampsia?

P
Population
151 nonpregnant women, including 101 with a history of preeclampsia (PE) and 50 parous women with a history of one or more successful normotensive pregnancies with comparable age, gestation, and parity profiles.
I
Intervention
Three-step preeclampsia prediction index based on medical examination, hemostasis/coagulation tests, and relative plasma volume.
O
Outcome
Derivation of a prediction index for identifying women at high risk for developing preeclampsia.surrogate

A stepwise prediction index utilizing clinical history, coagulation tests, and plasma volume can significantly increase the predictive probability of identifying women at high risk for preeclampsia.

Cite This Study

Emonts et al. (2008) studied this question.

synapsesocial.com/papers/6a7564aa96d04a2f43f59566https://doi.org/10.1080/10641950802000901
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prothrombotic Genotypes Are not Associated with Pre-eclampsia and Gestational Hypertension: Results from a Large Population-based Study and Systematic Review2002 · 185 citations
  2. 2Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials2002 · 278 citations
  3. 3Thromboembolic disease in pregnancy2000 · 19 citations