The plant potassium channel AKT2 exhibits two distinct gating modes controlled by post-translational factors, similar to the KCNK2 channel.
No immediate clinical implications for channelopathies; leaves open whether post-translational gating modes apply to human KCNK2.
Among the Shaker-like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous "leak-like" and time-dependent hyperpolarisation-activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole-cell and single-channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post-translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state.
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Drèyer et al. (2001) studied this question.
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