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March 17, 2015PLoS ONEOpen Access

Association between Arterial Stiffness and Serum L-Octanoylcarnitine and Lactosylceramide in Overweight Middle-Aged Subjects: 3-Year Follow-Up Study

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Why the study?

Does sustained overweight status increase arterial stiffness and alter plasma metabolites in middle-aged subjects?

Population

118 middle-aged subjects, comprising 59 individuals who remained overweight over a 3-year period and 59 age…

Comparison

Sustained overweight status over a 3-year period vs Normal weight over a 3-year period

Design

Cohort

Follow-up

3 years

Authors

MKMinjoo KimHannam UniversitySJSaem JungLG Chem (South Korea)SLSang‐Hyun LeeHanmi Pharmaceutical (South Korea)

Discussion

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Implication

Sustained overweight associates with arterial stiffness via metabolite changes; hypothesis-generating for causality and interventions in middle age.

Structured PICO

Does sustained overweight status increase arterial stiffness and alter plasma metabolites in middle-aged subjects?

P
Population
118 middle-aged subjects (aged 40-55 years), comprising 59 individuals who remained overweight over a 3-year period and 59 age- and gender-matched normal weight controls.
I
Intervention
Sustained overweight status over a 3-year period
C
Comparator
Normal weight over a 3-year period
O
Outcome
Changes in brachial-ankle pulse wave velocity (ba-PWV) and plasma metabolites over 3 yearssurrogate

Sustained overweight status in middle age is associated with increased arterial stiffness, which correlates with increases in specific plasma metabolites such as L-octanoylcarnitine and lactosylceramide.

Cite This Study

Kim et al. (2015) studied this question.

synapsesocial.com/papers/6a7569450aae7781f8032defhttps://doi.org/10.1371/journal.pone.0119519
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Also Consider

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