Why the study?
The site of lowest fatty acid permeability from capillary to cardiomyocyte and the relative contributions of unbound and albumin-bound pathways in delivering fatty acids to cellular membranes were unclear.
Concentration differences of unbound fatty acids drive intra-cardiac transfer, suggesting an active transport mechanism is not necessarily required.
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Boundary zones may limit cardiac FA uptake; leaves open whether modulating albumin interactions alters myocardial metabolism in vivo.
Vusse et al. (2022) studied this question.
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