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October 1, 1998Journal of Applied Physiology

Effect of simulated microgravity on vascular contractility

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Why the study?

Does simulated microgravity via hindlimb unweighting alter vascular contractility in rats?

Population

Sprague-Dawley (SD) and Wistar (W) rats

Comparison

Simulated microgravity via hindlimb unweighting… vs Control rats

Design

Preclinical

Follow-up

20 days

Authors

RPRalph E. PurdyNottingham University Hospitals NHS TrustSDSue P. DucklesUniversity of California, Los AngelesDKDiana N. KrauseLund University

Discussion

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Implication

Differential arterial-venous contractility changes in rat microgravity model; hypothesis-generating for human spaceflight physiology and countermeasures.

Structured PICO

Does simulated microgravity via hindlimb unweighting alter vascular contractility in rats?

P
Population
Sprague-Dawley (SD) and Wistar (W) rats
I
Intervention
Simulated microgravity via hindlimb unweighting (HU) using a tail harness for 20 days
C
Comparator
Control rats
O
Outcome
Isometric contraction of blood vessel rings (arteries and veins) in response to 68 mM K+ and norepinephrinesurrogate

Simulated microgravity reduces arterial, but not venous, contractility in rat models, suggesting differential vascular adaptation to weightlessness.

Cite This Study

Purdy et al. (1998) studied this question.

synapsesocial.com/papers/6a7572907324bb28b3e717e2https://doi.org/10.1152/jappl.1998.85.4.1307
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Also Consider

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  1. 1Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting1993 · 88 citations
  2. 2Cardiovascular variability and baroreceptor reflex sensitivity over a 14-day tail suspension in rats1995 · 28 citations
  3. 3Device for rapid quantification of human carotid baroreceptor-cardiac reflex responses1986 · 76 citations
  4. 4Handbook of Physiology.1960 · 10,377 citations
  5. 5Steroid potentiation of responses to sympathomimetic amines in aortic strips1969 · 134 citations