October 25, 2011Cardiovascular Research

Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats

View Full Paper

Ask AI

Bookmark

Population

Anaesthetized rats subjected to 10 min ligation of the left anterior descending coronary artery followed by…

Design

Preclinical

Follow-up

30 min reperfusion

Authors

MFMei FengPeking University JXJizhou XiangHuazhong University of Science and Technology ZMZhangyin MingHubei University of Education

Discussion

Member takes

Implication

Hypothesis-generating for EGFR inhibition against reperfusion arrhythmias; leaves open translation beyond rodent models.

Structured PICO

Population

Anaesthetized rats subjected to 10 min ligation of the left anterior descending coronary artery followed by 30 min reperfusion

Intervention

Pre-treatment with EGFR kinase inhibitor AG556 or intramyocardial transfection of EGFR siRNA

Outcome

Incidence and severity of cardiac arrhythmias (including ventricular fibrillation) during reperfusionsurrogate

EGFR activation mediates reperfusion-induced arrhythmias in rats, suggesting a potential novel mechanistic target for preventing reperfusion arrhythmias.

Cite This Study

Feng et al. (2011) studied this question.

synapsesocial.com/papers/6a75754701b447f0dadc2660 https://doi.org/10.1093/cvr/cvr281

View Full Paper

Ask AI

Bookmark

Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider