January 1, 1983The Journal of PhysiologyOpen Access

Effects of stimulation of aortic chemoreceptors on abdominal vascular resistance and capacitance in anaesthetized dogs.

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Population

Anaesthetized dogs, artificially ventilated, with vascularly isolated aortic arch, carotid sinuses, and…

Comparison

Stimulation of aortic body chemoreceptors. vs Baseline state and state after bilateral…

Design

Preclinical

Authors

RHR. HainsworthBoston Children's Hospital FKFazlul KarimCommonwealth Scientific and Industrial Research Organisation KMK. H. McGregorEuropean Society for Medical Oncology

Discussion

Member takes

Implication

Animal findings implicate vagosympathetic pathways in aortic chemoreceptor control of abdominal vessels; leaves open human translation and clinical relevance.

Structured PICO

Population

Anaesthetized dogs (chloralose), artificially ventilated, with vascularly isolated aortic arch, carotid sinuses, and abdominal circulation.

Intervention

Stimulation of aortic body chemoreceptors (by changing aortic arch perfusate from arterial to venous blood or by injection of sodium cyanide into the aortic arch).

Comparator

Baseline state (unstimulated) and state after bilateral cervical vagosympathetic trunk transection.

Outcome

Changes in abdominal vascular resistance (calculated from abdominal aortic perfusion pressure) and capacitance (integrated changes in venous outflow).surrogate

Stimulation of aortic chemoreceptors causes reflex constriction of both resistance and capacitance vessels in the abdominal circulation, mediated by vagosympathetic pathways.

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Hainsworth et al. (1983) studied this question.

synapsesocial.com/papers/6a7579ce0199417375e718fe https://doi.org/10.1113/jphysiol.1983.sp014503

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Implication

Animal findings implicate vagosympathetic pathways in aortic chemoreceptor control of abdominal vessels; leaves open human translation and clinical relevance.

Effects of stimulation of aortic chemoreceptors on abdominal vascular resistance and capacitance in anaesthetized dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of stimulation of aortic chemoreceptors on abdominal vascular resistance and capacitance in anaesthetized dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider