Why the study?
Can a clinical prediction model accurately predict the risk of an INR ≥ 4.5 in hospitalized patients treated with vitamin K antagonists?
Population
8,996 admissions of adult patients admitted to a tertiary hospital and treated with vitamin K antagonists
Design
Cohort
Follow-up
during hospital stay
Authors
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Prediction model for supratherapeutic INR on VKAs is hypothesis-generating; external validation required before any clinical use.
Can a clinical prediction model accurately predict the risk of an INR ≥ 4.5 in hospitalized patients treated with vitamin K antagonists?
A newly developed clinical prediction model using routine electronic health record data can predict the risk of supratherapeutic INR (≥4.5) in hospitalized patients on VKAs with moderate discrimination.
Dreijer et al. (2018) studied this question.
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