Prevalence and related factors of thyroid autoantibodies positive in children with type 1 diabetes mellitus

Objective To analyze the incidence of thyroid antibodies positive in children with type 1 diabetes mellitus (T1DM) and its related factors, and provide evidence for clinical diagnosis and treatment. Methods The clinical data of 107 children with T1DM diagnosed in Chinldren’s Hospital Affiliated to Zhengzhou University from January 2014 to January 2017 were collected and analyzed retrospectively to master the positive rate of thyroid autoantibodies in children, and to compare the relationship between thyroid function and T lymphocyte in positive group and negative group. Results Among the 107 selected cases, 25 cases (23.4%) had positive thyroid autoantibodies, including 22 cases of double antibody positive and 82 cases of normal (76.6%). The family history ratio and age of the children in positive group were higher than those in negative group (P<0.05). The abnormal rate of thyroid stimulating hormone (TSH) in positive group was significantly higher than that in negative group (P<0.05). The levels of CD3+ and CD4+ in positive group were significantly higher than those in negative group (P<0.05). Conclusions Children with T1DM and thyroid autoantibody positive are prone to have thyroid dysfunction, and the high positive rate of thyroid autoantibodies positive is associated with genetic factors and abnormal T cell immune function.