Population
cPVR mouse model and cell culture infected with poliovirus
Comparison
H273R poliovirus vs Wild-type (WT) poliovirus
Design
Preclinical
Authors
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Hypothesis-generating for fidelity modulation in poliovirus attenuation; human studies needed before clinical consideration.
Optimal RNA-dependent RNA polymerase fidelity is a key determinant of viral virulence, suggesting a potential target for viral attenuation or antiviral therapies.
Korboukh et al. (2014) studied this question.
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