Key result
High-fidelity replication in foot-and-mouth disease virus variants was associated with restricted quasispecies diversity and significantly attenuated virulence.
Higher replication fidelity in FMDV is associated with a more attenuated virus, suggesting that modulating replication fidelity could be a strategy for designing live attenuated vaccines.
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High-fidelity FMDV replication attenuates virulence; hypothesis-generating for fidelity modulation in live vaccines, validation needed beyond animal models.
Zeng et al. (2014) studied Foot-and-mouth disease virus (FMDV). Ribavirin-resistant FMDV high-fidelity RdRp variants vs. Wild-type or non-high-fidelity mutants was evaluated on Viral replication fidelity and virulence. High-fidelity replication in foot-and-mouth disease virus variants was associated with restricted quasispecies diversity and significantly attenuated virulence.
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