Population
In vitro kinetic analysis of wild-type and mutant foot-and-mouth disease virus 3Dpol and poliovirus 3Dpol
Comparison
Kinetic analysis of nucleotide addition and… vs Wild-type FMDV 3Dpol and PV 3Dpol
Design
Preclinical
Authors
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Reduces ribavirin incorporation without high fidelity in FMDV; leaves open implications for resistance mechanisms in vivo.
The FMDV M296I mutant polymerase decreases ribavirin incorporation while increasing natural nucleotide misincorporation, demonstrating that not all ribavirin-resistant mutants encode high-fidelity polymerases.
Arias et al. (2008) studied this question.
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