Continuous electrical stimulation induces the expression of slow myosin isoforms in fast muscles of the rat hind limb, contrary to previous reports.
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Challenges prior reports on myosin isoform switching in rat muscle; leaves open translation to human cardiac or skeletal plasticity.
Fast muscles of the rat hind limb were stimulated continuously at 10 or 20 Hz for periods of 55-61 days by means of an implantable neuromuscular stimulator. Gel electrophoresis clearly demonstrated the presence in stimulated muscles of slow myosin light and heavy chains, although fast isoforms were still present in all cases. Thus, contrary to previous reports, induction of slow myosin isoforms does occur in this, as in other, mammalian species. The time course of the response to stimulation appears to be more extended than that seen in the rabbit.
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Mayne et al. (1993) studied this question.
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