Key result
Chronic low-frequency stimulation of rabbit fast-twitch muscle induces progressive increases in slow myosin light and heavy chain mRNAs, an effect more pronounced than in rat muscle.
Chronic low-frequency stimulation induces a more pronounced fast-to-slow transition of myosin isoforms at the mRNA level in rabbit fast-twitch muscle compared to rats.
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Species differences in myosin mRNA induction warrant caution in extrapolating to humans; leaves open relevance for cardiac or skeletal muscle plasticity.
Chronic low-frequency stimulation of rabbit fast-twitch muscle induces progressive increases in slow myosin light chain mRNAs followed by an increase in the slow myosin heavy chain HCI mRNA. Therefore, the effects of chronic stimulation are more pronounced in rabbit than in rat fast-twitch muscle. The latter responds mainly with a rearrangement of its fast isomyosin pattern.
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Kirschbaum et al. (1989) studied this question. Chronic low-frequency stimulation of rabbit fast-twitch muscle induces progressive increases in slow myosin light and heavy chain mRNAs, an effect more pronounced than in rat muscle.
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