July 30, 1990FEBS LettersOpen Access

Rapid and reversible changes in myosin heavy chain expression in response to increased neuromuscular activity of rat fast‐twitch muscle

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Population

rat fast-twitch muscle

Design

Preclinical

Follow-up

15 days

Authors

BKBernhard J. KirschbaumMerck Serono (Italy)SSSusanne A. SchneiderUniversity of Kassel SISeigo IzumoBeth Israel Deaconess Medical Center

Discussion

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Implication

Stimulation-induced myosin plasticity is rapid and reversible in rat muscle; leaves open translation to human cardiac or skeletal remodeling.

Structured PICO

Population

rat fast-twitch muscle

Intervention

Chronic 10 Hz stimulation for up to 15 days

Outcome

tissue levels of fast myosin heavy chain (HC) mRNA isoforms (HCIIb and HCIIa)surrogate

Chronic 10 Hz stimulation of rat fast-twitch muscle induces rapid and reversible down-regulation of the HCIIb gene and up-regulation of the HCIIa gene.

Cite This Study

Kirschbaum et al. (1990) studied this question.

synapsesocial.com/papers/6a96387343a7cf2fc0d7b191 https://doi.org/10.1016/0014-5793(90)80976-p

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Implication

Stimulation-induced myosin plasticity is rapid and reversible in rat muscle; leaves open translation to human cardiac or skeletal remodeling.

Rapid and reversible changes in myosin heavy chain expression in response to increased neuromuscular activity of rat fast‐twitch muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid and reversible changes in myosin heavy chain expression in response to increased neuromuscular activity of rat fast‐twitch muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider