Key result
Continuous electrical stimulation of rabbit fast-twitch muscles replaced fast MHC mRNA with slow MHC mRNA, a process that reversed during recovery.
Population
Rabbit fast-twitch muscles (tibialis anterior and extensor digitorum longus)
Design
Preclinical
Follow-up
Up to 3 weeks of stimulation, and 12 days of recovery
Authors
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Animal findings on muscle stimulation should not guide clinical decisions; leaves open whether mechanisms translate to human neuromuscular conditions.
Chronic electrical stimulation of rabbit fast-twitch muscle induces a reversible shift from fast to slow myosin heavy chain mRNA expression.
Brownson et al. (1992) studied this question. Continuous electrical stimulation was evaluated on Changes in myosin heavy chain (MHC) mRNAs. Continuous electrical stimulation of rabbit fast-twitch muscles replaced fast MHC mRNA with slow MHC mRNA, a process that reversed during recovery.
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