Key result
Continuous stimulation of rabbit fast muscle at 10 Hz caused individual preexisting muscle fibers to switch from synthesizing fast myosin to slow myosin, evidenced by progressive changes in staining.
Chronically stimulated rabbit fast muscle fibers can switch from synthesizing fast myosin to slow myosin within the same preexisting fibers.
No takes yet. Share an insight, caveat, or question.
Reveals myosin isoform switching within preexisting skeletal muscle fibers; leaves open relevance to human cardiac remodeling or therapeutic stimulation.
Rubinstein et al. (1978) studied Muscle fiber transformation. Continuous stimulation vs. Unstimulated fast peroneus longus muscle was evaluated on Staining intensity with fast (AF) and slow (AS) muscle myosins. Continuous stimulation of rabbit fast muscle at 10 Hz caused individual preexisting muscle fibers to switch from synthesizing fast myosin to slow myosin, evidenced by progressive changes in staining.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: