What does this research mean for the field?

Continuous stimulation of fast muscle causes individual preexisting muscle fibers to switch from synthesizing fast myosin to slow myosin, rather than replacing fiber populations via atrophy and de novo synthesis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1978The Journal of Cell BiologyOpen Access

Use of type-specific antimyosins to demonstrate the transformation of individual fibers in chronically stimulated rabbit fast muscles.

Q: What is the clinical evidence from this study?

Population: Muscle fiber transformation. Intervention: Continuous stimulation vs. Unstimulated fast peroneus longus muscle. Primary outcome: Staining intensity with fast (AF) and slow (AS) muscle myosins.

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Key result

Continuous stimulation of rabbit fast muscle at 10 Hz caused individual preexisting muscle fibers to switch from synthesizing fast myosin to slow myosin, evidenced by progressive changes in staining.

Population

Rabbit fast muscle (peroneus longus)

Comparison

Continuous stimulation at 10 Hz vs Unstimulated fast peroneus longus muscle

Design

Preclinical

Authors

NRNeal A. RubinsteinUniversity of Pennsylvania KMK. MabuchiBrigham and Women's Hospital FPFrank A. PepeKing's College London

Discussion

Member takes

Implication

Reveals myosin isoform switching within preexisting skeletal muscle fibers; leaves open relevance to human cardiac remodeling or therapeutic stimulation.

Structured PICO

Population

Rabbit fast muscle (peroneus longus)

Intervention

Continuous stimulation at 10 Hz

Comparator

Unstimulated fast peroneus longus muscle

Outcome

Expression of fast and slow muscle myosins assessed by fluorescein-labeled antibodies (AF and AS)surrogate

Chronically stimulated rabbit fast muscle fibers can switch from synthesizing fast myosin to slow myosin within the same preexisting fibers.

Cite This Study

Rubinstein et al. (1978) studied Muscle fiber transformation. Continuous stimulation vs. Unstimulated fast peroneus longus muscle was evaluated on Staining intensity with fast (AF) and slow (AS) muscle myosins. Continuous stimulation of rabbit fast muscle at 10 Hz caused individual preexisting muscle fibers to switch from synthesizing fast myosin to slow myosin, evidenced by progressive changes in staining.

synapsesocial.com/papers/6a1746fb3d715b2f195dfa3d https://doi.org/10.1083/jcb.79.1.252

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Implication

Reveals myosin isoform switching within preexisting skeletal muscle fibers; leaves open relevance to human cardiac remodeling or therapeutic stimulation.

Use of type-specific antimyosins to demonstrate the transformation of individual fibers in chronically stimulated rabbit fast muscles.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Use of type-specific antimyosins to demonstrate the transformation of individual fibers in chronically stimulated rabbit fast muscles.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider