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This study aims to explore the relationship between different types of diuretics and the risk of developing gout.

Use of Diuretics and Risk of Incident Gout: A Population‐Based Case–Control Study

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This study aims to explore the relationship between different types of diuretics and the risk of developing gout.
Conducted a retrospective population-based case-control analysis using the General Practice Research Database in the UK.
Identified 91,530 incident cases of gout and matched each with control cases based on demographics and medical history.
Used conditional logistic regression to calculate odds ratios (ORs) for different diuretic classes.
Current use of loop diuretics associated with an adjusted OR of 2.64 (95% CI 2.47-2.83) for incident gout.
Thiazide diuretics and thiazide-like diuretics had adjusted ORs of 1.70 (95% CI 1.62-1.79) and 2.30 (95% CI 1.95-2.70), respectively.
Combined use of loop diuretics and thiazide diuretics yielded the highest risk estimate for gout at an adjusted OR of 4.65 (95% CI 3.51-6.16).

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Case–control study investigates diuretic use and gout risk, indicating increased risk with certain diuretics.

Bruderer et al. (2013) studied this question.

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