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March 1, 1955Annals of Human Genetics

An Aetiological Study of Congenital Heart Disease

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Population

377 families containing children with congenital heart disease, seen at Guy's Hospital. Excluded: mongolism…

Design

Cross-sectional

Authors

PPP. E. PolaniGuy's HospitalMCMaurice CampbellGuy's Hospital

Discussion

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Implication

Elevated sibling recurrence may guide family counseling; leaves open precise modern risks pending prospective confirmation.

Structured PICO

P
Population
377 families containing children with congenital heart disease (divided into Fallot's tetralogy, other cyanotic, and acyanotic groups), seen at Guy's Hospital. Excluded: mongolism (n=5) and maternal rubella (n=2).
O
Outcome
Aetiological factors including parental age, birth rank, seasonal incidence, sex distribution, sibling incidence, and associated malformations

This study demonstrated a 20-fold increased incidence of congenital heart disease among siblings of affected children compared to the general population.

Cite This Study

Polani et al. (1955) studied this question.

synapsesocial.com/papers/6a7584fc12165deef3dd7b8bhttps://doi.org/10.1111/j.1469-1809.1955.tb01345.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SEASONAL INCIDENCE OF PATENT DUCTUS ARTERIOSUS AND MATERNAL RUBELLA1952 · 53 citations
  2. 2FAMILIAL DATA ON 144 CASES OF ANENCEPHALY, SPINA BIFIDA AND CONGENITAL HYDROCEPHALY1946 · 65 citations
  3. 3Twinning in Twin Pedigrees1950 · 57 citations