Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway
Population
Mice and neonatal rat cardiac myocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for miR-146a inhibition in doxorubicin cardiotoxicity; leaves open clinical translation to reduce trastuzumab-related heart failure risk.
Structured PICO
P
Population
Mice and neonatal rat cardiac myocytes
I
Intervention
Doxorubicin treatment, miR-146a overexpression, and miR-146a decoy genes
O
Outcome
ErbB4 expression and cardiomyocyte cell deathsurrogate
Acute doxorubicin cardiotoxicity is mediated by miR-146a up-regulation, which inhibits the cardioprotective ErbB4 pathway, providing a mechanistic link for the increased heart failure risk when combined with trastuzumab.
Cite This Study
Horie et al. (2010) studied this question.