Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2002Journal of Cardiovascular Pharmacology

Proarrhythmic Effects of Intravenous Quinidine, Amiodarone, d -Sotalol, and Almokalant in the Anesthetized Rabbit Model of Torsade de Pointes

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do intravenous quinidine, amiodarone, D-sotalol, and almokalant evoke Torsade de Pointes in an anesthetized rabbit model?

Population

Chloralose-anesthetized rabbits during alpha1-adrenoceptor stimulation

Design

Preclinical

Authors

AFAndrás FarkasUniversity of FloridaILIstván LepránUniversity of SzegedJPJulius Gy. PappElectrophysiology

Discussion

Loading...

Member takes

Overview

Rabbit model may yield false negatives for quinidine/amiodarone; leaves open its predictive value for clinical TdP risk.

Structured PICO

Do intravenous quinidine, amiodarone, D-sotalol, and almokalant evoke Torsade de Pointes in an anesthetized rabbit model?

P
Population
Chloralose-anesthetized rabbits during alpha1-adrenoceptor stimulation
I
Intervention
Intravenous infusion of almokalant (26, 88, and 260 microg/kg), D-sotalol, quinidine, or amiodarone (each 3, 10, and 30 mg/kg) over 5 min with 20-min intervals between doses
O
Outcome
Incidence of Torsade de Pointes (TdP) and other arrhythmiassafety

In an anesthetized rabbit model, D-sotalol and almokalant frequently induced Torsade de Pointes, while quinidine and amiodarone did not, highlighting potential false-negative limitations of the model for certain drugs.

Limitations

  • Lack of TdP with quinidine warns of false-negative results in the applied model

Cite This Study

Farkas et al. (2002) studied this question.

synapsesocial.com/papers/6a7588a0756843cacbb20fc2https://doi.org/10.1097/00005344-200202000-00016
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early Proarrhythmia During Intravenous Amiodarone Treatment1999 · 16 citations
  2. 2Quinidine is a competitive antagonist at alpha 1- and alpha 2-adrenergic receptors.1984 · 39 citations
  3. 3Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide‐sensitive K+ currents in Xenopus oocytes1993 · 33 citations
  4. 4Nonselective IKr-Blockers Do not Induce Torsades de Pointes in the Anesthetized Rabbit During α1-Adrenoceptor Stimulation2000 · 39 citations
  5. 5Torsade de pointes1993 · 101 citations